Ultanir
lab
Kinases and Brain Development Laboratory
Roles of kinases in brain development and function
Our research goal is to identify kinase signaling mechanisms that regulate formation, functioning and maintenance of nervous system with particular emphasis of disease-relevant kinases and signaling pathways.
Better understanding of kinase signaling pathways would facilitate the pursuit of targeted treatments for neurological diseases. Accurate disease-relevant phosphorylation sites can be used as preclinical and clinical molecular biomarkers.
We develop mouse models of neurological conditions and study these models in proteomic, transcriptomic and genomic assays. We use chemical genetics and mass spectrometry methods to reveal novel kinase signaling pathways on neuronal development, synaptogenesis and epilepsy.
We study CDKL5, mTOR, TNIK and the NDR family of kinases.
collaborators
Academic collaborators
Gabriele Lignani, UCL, Institute of Neurology
Joseph Bateman, King’s College London
Juan Burrone, King’s College London
Jernej Ule, King’s College London, UK Dementia research institute
Tim Benke, University of Colorado, USA
Florencia Iacaruso, Francis Crick Institute
Max Gutierrez, Francis Crick Institute
Alison Axtman, University of North Carolina, USA
The Ultanir lab
