Rupert worked with Doug Fearon during his undergraduate medical degree and became fascinated by immunology. He undertook a PhD in the MRC Laboratory of Molecular Biology with the late Michael Neuberger as part of the Cambridge MB/PhD programme.

During his higher medical training as a clinical lecturer in nephrology, he returned to the LMB to work with Felix Randow, where he discovered a surprising direct interaction between influenza and the autophagy machinery. 

He then set up his own laboratory in Cambridge with the support of a MRC Clinician Scientist Fellowship, before moving to the Crick as the first of a new set of clinical group leaders.

Qualifications and history

2005
University of Cambridge/MRC LMB
MB/PhD
2007
MRCP
Junior hospital doctor
2013
University of Cambridge, UK
Clinical Lecturer in Nephrology and Immunology
2014
Royal Free Hospital, London, UK
Consultant Nephrologist
2015
Division of Virology, Department of Pathology, University of Cambridge
MRC Clinician Scientist Fellow and Group Leader
2019
The Francis Crick Institute, London, UK
Group Leader
2019
Royal Free Hospital, London, UK
Honorary Consultant Nephrologist

Crick Pre-Crick

Displaying 1 - 20 of 74
Last updated : 03 March 2026 03:57

SARS-CoV-2 envelope protein induces LC3 lipidation via the V-ATPase-ATG16L1 axis

Preprint
Authors (19)
  • Carmen Figueras-Novoa
  • Lewis Timimi
  • Elena Marcassa
  • Raquel Taveira-Marques
  • Lorin Adams
  • Ming Jiang
  • [...]
  • Ruth Harvey
  • Arvind H Patel
  • Michael Howell
  • Rachel Ulferts
  • Rupert Beale
bioRxiv
Published
Crick labs/ facilities
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Real-time estimation of immunological responses against emerging SARS-CoV-2 variants in the UK: a mathematical modelling study

Authors (44)
  • Timothy W Russell
  • Hermaleigh Townsley
  • Joel Hellewell
  • Joshua Gahir
  • Marianne Shawe-Taylor
  • David Greenwood
  • [...]
  • Mary Wu
  • David LV Bauer
  • Edward Carr
  • Emma Wall
  • Adam J Kucharski
The Lancet Infectious Diseases
Published
Crick labs/ facilities
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The V-ATPase/ATG16L1 axis is controlled by the V1H subunit

Authors (15)
Molecular Cell
Published
Crick labs/ facilities
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Immunogenicity of third dose COVID-19 vaccine strategies in patients who are immunocompromised with suboptimal immunity following two doses (OCTAVE-DUO): an open-label, multicentre, randomised, controlled, phase 3 trial

Authors (48)
  • Carl S Goodyear
  • Amit Patel
  • Eleanor Barnes
  • Michelle Willicombe
  • Stefan Siebert
  • Thushan I de Silva
  • [...]
  • David Thomas
  • Amanda Kirkham
  • Iain B McInnes
  • Pamela Kearns
  • OCTAVE-DUO investigators
The Lancet Rheumatology
Published
Crick labs
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COVID-19 in non-hospitalised adults caused by either SARS-CoV-2 sub-variants Omicron BA.1, BA.2, BA.4/5 or Delta associates with similar illness duration, symptom severity and viral kinetics, irrespective of vaccination history

Authors (37)
PLOS ONE
Published
Crick labs/ facilities
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Combined analyses of within-host SARS-CoV-2 viral kinetics and information on past exposures to the virus in a human cohort identifies intrinsic differences of Omicron and Delta variants

Authors (26)
PLOS Biology
Published
Crick labs/ facilities
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SARS-CoV-2 mucosal neutralising immunity after vaccination

Authors (38)
The Lancet Infectious Diseases
Published
Crick labs/ facilities
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