Rinako Nakagawa

Principal Laboratory Research Scientist

I have been interested in the dynamic regulation of the germinal centre (GC) response. GCs form in secondary lymphoid organs and play a key role for the differentiation of high-affinity antibody secreting plasma cells and memory-B cells; those cells provide a framework of vaccination. To increase affinity of an antibody, GCs select high-affinity B cells for further proliferation. My interest is particularly within GC selection mechanisms and differentiation of selected cells that are defined as positivity for cMyc and microRNA(miR)-155. Also, I am interested in immunoregulation via miR-155.

Displaying 1 - 12 of 12
Last updated : 03 March 2026 02:37

Epi-microRNA mediated metabolic reprogramming counteracts hypoxia to preserve affinity maturation

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Nature Communications
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GEO entry GSE230528: Analysis of transcriptomes of germinal center (GC) B cells derived from miR-155-sufficient and -deficient mice at the single-cell level [scRNA-seq]

Authors (3)
Gene Expression Omnibus (GEO)
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Regulation of BCR-mediated Ca2+ mobilization by MIZ1-TMBIM4 safeguards IgG1+ GC B cell-positive selection

Authors (14)
Science Immunology
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Permissive selection followed by affinity-based proliferation of GC light zone B cells dictates cell fate and ensures clonal breadth

Authors (11)
Proceedings of the National Academy of Sciences of the United States of America
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Restriction of memory B cell differentiation at the germinal center B cell positive selection stage

Authors (13)
Journal of Experimental Medicine
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