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Our mission is to pursue scientific research without boundaries. We aim for our research to be open, accessible and reproducible.

We publish the new ideas, knowledge and techniques that emerge from Crick research as peer-reviewed papers.

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We've collected some of the most significant papers published by Crick researchers so far.

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Publications

Displaying 1 - 20 of 63
Last updated : 03 March 2026 02:38

Design of a potent, selective, and brain-penetrant inhibitor of Wnt-deactivating enzyme Notum by optimization of a crystallographic fragment hit

Authors (24)
  • Nicky J Willis
  • William Mahy
  • James Sipthorp
  • Yuguang Zhao
  • Hannah L Woodward
  • Benjamin N Atkinson
  • [...]
  • Patricia C Salinas
  • Jean-Paul Vincent
  • E Yvonne Jones
  • Paul Whiting
  • Paul V Fish
Journal of Medicinal Chemistry
Published
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