The latest publications from the Crick
Intro
Our mission is to pursue scientific research without boundaries. We aim for our research to be open, accessible and reproducible.
We publish the new ideas, knowledge and techniques that emerge from Crick research as peer-reviewed papers.
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Publication highlights
We've collected some of the most significant papers published by Crick researchers so far.
View the highlightsPublications
Year published
Teams
- Adam Sateriale (3)
- Adrian Hayday (81)
- Alberto Elosegui Artola (2)
- Alessandro Costa (16)
- Alex Gould (24)
- Andrea Serio (1)
- Andreas Schaefer (1)
- Andreas Wack (45)
- Anne O’Garra (42)
- Anne Schreiber (6)
- Axel Behrens (49)
- Bart de Strooper | Lorena Arancibia (8)
- Benedikt Berninger (2)
- Ben Schumann (2)
- Bioinformatics and Biostatistics (296)
- Biological Research Facility (349)
- Caetano Reis e Sousa (57)
- Carola Vinuesa (25)
- Caroline Hill (24)
- Cell Science (78)
- Charles Swanton (69)
- Chemical Biology (5)
- Cristina Lo Celso (3)
- David LV Bauer (33)
- David Riglar (2)
- David Wilkinson (17)
- Dinis Calado (34)
- Dominique Bonnet (15)
- Edith Heard (1)
- Ed Tate (12)
- Edward Carr (20)
- Electron Microscopy (82)
- Erik Sahai (80)
- Experimental Histopathology (156)
- Fermentation (37)
- Flow Cytometry (239)
- Folkert van Werven (20)
- Francesca Ciccarelli (3)
- Francois Guillemot (58)
- Frank Uhlmann (64)
- Genetic Modification Service (58)
- Genomics (265)
- George Kassiotis (93)
- Gerard Evan (1)
- Gitta Stockinger (17)
- Hasan Yardimci (2)
- Human Biology Facility (19)
- Human Embryonic Stem Cell (9)
- Ian Taylor (47)
- Ilaria Malanchi (39)
- In Vivo Imaging (25)
- Irene Miguel-Aliaga (7)
- James Briscoe (111)
- James DiFrisco (3)
- James Lee (2)
- James Turner (40)
- Jean-Paul Vincent (39)
- Jeremy Carlton (3)
- Jernej Ule | Ben Blencowe (6)
- John Diffley (50)
- Jonathan Stoye (38)
- Julian Downward (61)
- Jurg Bahler (3)
- Karen Vousden (8)
- Kate Bishop (14)
- Katharina Schmack (3)
- Katrin Rittinger (2)
- Leanne Li (1)
- Light Microscopy (192)
- Louise Walport (1)
- Lucia Prieto-Godino (1)
- Making Lab (3)
- Marco Di Antonio (6)
- Margarida Cardoso-Moreira (5)
- Mariia Yuneva (32)
- Marika Charalambous (1)
- Mariya Moosajee (73)
- Markus Ralser (8)
- Martin Singleton (14)
- Maximiliano Gutierrez (68)
- Maxim Molodtsov (6)
- Media Preparation (3)
- Metabolomics (52)
- Michael Way (78)
- Mike Devine (2)
- MRC Biomedical NMR Centre (27)
- Naomi Moris (1)
- Nathan Goehring (17)
- Neil McDonald (9)
- Nicola Lewis (23)
- Nic Tapon (23)
- Paola Bonfanti (2)
- Paola Scaffidi (2)
- Patricia Barral (13)
- Paul Bates (14)
- Paul Nurse (78)
- Pavel Tolar (8)
- Peter Cherepanov (18)
- Peter Parker (12)
- Peter Ratcliffe (2)
- Peter Rosenthal (44)
- Peter Van Loo (17)
- Pietro Fratta (1)
- Proteomics (134)
- Radoslav Enchev (2)
- Rashmi Priya (12)
- Richard Treisman (17)
- Rickie Patani (7)
- Robert J Wilkinson (280)
- Robin Lovell-Badge (76)
- Rupert Beale (36)
- Samra Turajlic (20)
- Sam Rodriques (1)
- Scientific computing (76)
- Screening and Automated Science (93)
- Sharon Tooze (89)
- Sila Ultanir (6)
- Simon Boulton (74)
- Snezhka Oliferenko (4)
- Sonia Gandhi (30)
- Stephen West (7)
- Steve Gamblin (43)
- Structural Biology (161)
- Translation team (7)
- Vassilis Pachnis (38)
- Venizelos Papayannopoulos (9)
- Veronica Kinsler (2)
- Victor Tybulewicz (61)
- Viral and Immune Surveillance Platform (12)
- Vivian Li (6)
- Willie Taylor (4)
- Worldwide Influenza Centre (41)
Publication type
Journal
- 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 (2)
- Accounts of Chemical Research (1)
- ACS Applied Materials and Interfaces (1)
- ACS Central Science (1)
- ACS Chemical Biology (1)
- ACS Chemical Neuroscience (1)
- ACS Infectious Diseases (4)
- ACS Omega (1)
- Acta Crystallographica Section F: Structural Biology Communications (1)
- Acta Naturae (1)
- Acta Neuropathologica Communications (1)
- Advanced Healthcare Materials (1)
- Advanced Materials (1)
- Advanced Therapeutics (1)
- Advances in Clinical Neuroscience and Rehabilitation (1)
- Advances in Immunology (1)
- Advances in Ophthalmology and Optometry (1)
- Aging (1)
- Aging Cell (3)
- AIDS (3)
- AIDS Research and Therapy (1)
- ALTEX (1)
- Alzheimer's and Dementia (2)
- Alzheimer's Research and Therapy (2)
- American Journal of Bioethics (1)
- American Journal of Human Genetics (2)
- American Journal of Medical Genetics Part A (1)
- American Journal of Psychiatry (1)
- American Journal of Respiratory and Critical Care Medicine (4)
- American Journal of Respiratory Cell and Molecular Biology (3)
- American Journal of Tropical Medicine and Hygiene (1)
- Analytical Chemistry (1)
- Anatomical Record (1)
- Angewandte Chemie International Edition (2)
- Animals (1)
- Animal Technology and Welfare (11)
- Animal Welfare (1)
- Annals of the American Thoracic Society (2)
- Annals of the New York Academy of Sciences (3)
- Annals of the Rheumatic Diseases (1)
- Annals of Translational Medicine (3)
- Annual Review of Biochemistry (2)
- Annual Review of Cancer Biology (1)
- Annual Review of Cell and Developmental Biology (4)
- Annual Review of Genetics (1)
- Annual Review of Genomics and Human Genetics (1)
- Annual Review of Immunology (6)
- Annual Review of Microbiology (1)
- Antimicrobial Agents and Chemotherapy (7)
- Antioxidants (2)
- Applied Materials Today (1)
- Archives of Disease in Childhood (1)
- Arthritis & Rheumatology (2)
- Australian Journal of Forensic Sciences (1)
- Autophagy (18)
- Autophagy Reports (2)
- Bio-Protocol (1)
- Biochemical Journal (12)
- Biochemical Society Transactions (4)
- Biochemistry (1)
- Biochimica et Biophysica Acta (4)
- Biochimica et Biophysica Acta - Molecular Basis of Disease (1)
- Biochimica et Biophysica Acta: Molecular Basis of Disease (1)
- BioEssays (5)
- Biographical Memoirs of the Fellows of the Royal Society (1)
- Bioinformatics (4)
- Biologist (1)
- Biology (3)
- Biology of Reproduction (1)
- Biology of Sex Differences (1)
- Biology of the Cell (1)
- Biology Open (5)
- Biol Open (1)
- Biomedical Optics Express (2)
- Biomedicines (2)
- Biomolecular NMR Assignments (1)
- Biomolecules (1)
- Biophysica (1)
- BioRxiv (3)
- Bioscience Reports (1)
- BJR Case Reports (1)
- Blood (7)
- Blood Advances (1)
- Blood Cancer Discovery (2)
- Blood Cancer Journal (1)
- BMC Bioinformatics (1)
- BMC Biology (8)
- BMC developmental biology (2)
- BMC Genomics (1)
- BMC Immunology (1)
- BMC Infectious Diseases (3)
- BMC Medicine (2)
- BMC Pediatrics (1)
- BMC Research Notes (4)
- BMC Structural Biology (1)
- BMJ Open (2)
- BMJ Open Ophthalmology (3)
- BMJ Open Respiratory Research (1)
- BMJ Open Sport & Exercise Medicine (1)
- Bone (1)
- Bone Research (1)
- Brain (5)
- Brain Communications (2)
- Breast Cancer Research (1)
- British Journal of Anaesthesia (1)
- British Journal of Cancer (3)
- British Journal of Clinical Pharmacology (1)
- British Journal of Ophthalmology (1)
- British Journal of Pharmacology (1)
- Canadian Journal of Cardiology (1)
- Cancer Biomarkers (1)
- Cancer Cell (14)
- Cancer Discovery (6)
- Cancer Immunology Research (3)
- Cancer Letters (1)
- Cancer Research (10)
- Cancer Research Communications (1)
- Cancers (6)
- Cardiology in the Young (6)
- Cardiovascular Research (2)
- Cell (41)
- Cell Chemical Biology (3)
- Cell Cycle (2)
- Cell Death and Differentiation (3)
- Cell Death and Disease (3)
- Cell Discovery (2)
- Cell Host and Microbe (8)
- Cell Metabolism (1)
- Cell Reports (60)
- Cell Reports Medicine (1)
- Cell Reports Methods (4)
- Cells (5)
- Cell Stem Cell (10)
- Cell systems (6)
- Cellular and Molecular Immunology (2)
- Cellular and Molecular Life Sciences (3)
- Cellular Microbiology (10)
- Cerebral Cortex (3)
- Chemical Science (1)
- Chemistry–Methods (1)
- Chromosoma (4)
- Circulation: Arrhythmia and Electrophysiology (1)
- Circulation Research (1)
- Clinical Anatomy (1)
- Clinical and Experimental Metastasis (1)
- Clinical and Translational Immunology (1)
- Clinical cancer research (3)
- Clinical Genetics (2)
- Clinical Infectious Diseases (15)
- Clinical Medicine (2)
- Clinical Microbiology and Infection (1)
- Clinical Pharmacokinetics (1)
- Cold Spring Harbor Perspectives in Biology (5)
- Cold Spring Harbor Perspectives in Medicine (2)
- Cold Spring Harbor Protocols (3)
- Communications Biology (2)
- Communications in Mathematical Sciences (1)
- Computational and Structural Biotechnology Journal (1)
- Critical Care Explorations (1)
- Crystals (1)
- Current Biology (19)
- Current Eye Research (1)
- Current Genetics (5)
- Current Issues in Molecular Biology (1)
- Current Opinion in Cell Biology (11)
- Current Opinion in Genetics and Development (2)
- Current Opinion in HIV and AIDS (2)
- Current Opinion in Immunology (4)
- Current Opinion in Microbiology (2)
- Current Opinion in Neurobiology (1)
- Current Opinion in Neurology (1)
- Current Opinion in Pharmacology (1)
- Current Opinion in Rheumatology (1)
- Current Opinion in Structural Biology (2)
- Current Protocols (1)
- Current Protocols in Neuroscience (1)
- Current Research in Immunology (2)
- Current Topics in Behavioral Neurosciences (1)
- Current Topics in Developmental Biology (11)
- Current Treatment Options in Neurology (1)
- Cytometry Part A (2)
- Database (1)
- Development (75)
- Developmental Biology (11)
- Developmental Cell (47)
- Developmental Dynamics (1)
- Developmental Neurobiology (1)
- Diabetes, Obesity and Metabolism (1)
- Diabetes Research and Clinical Practice (1)
- Digital Health (1)
- Disease Models & Mechanisms (3)
- Disease Models and Mechanisms (6)
- DNA Repair (2)
- EBioMedicine (5)
- Ecancermedicalscience (1)
- EClinicalMedicine (2)
- EJNMMI Research (1)
- eLife (70)
- EMBO Journal (28)
- EMBO Molecular Medicine (9)
- EMBO Reports (14)
- Emerging Infectious Diseases (1)
- Endocrine Connections (1)
- Endocrinology (1)
- eNeuro (1)
- ESC Heart Failure (1)
- ESMO Open (2)
- Essays in Biochemistry (1)
- Europace (2)
- European Journal of Human Genetics (1)
- European Journal of Immunology (10)
- European Journal of Medicinal Chemistry (1)
- European Respiratory Journal (9)
- European Respiratory Review (2)
- Europhysics News (1)
- Experimental and Molecular Pathology (1)
- Experimental Cell Research (1)
- Experimental Eye Research (1)
- Expert Opinion on Drug Safety (1)
- Expert Opinion on Pharmacotherapy (3)
- Expert opinion on therapeutic targets (2)
- Expert Review of Respiratory Medicine (2)
- Eye (2)
- F1000Research (3)
- Faculty Reviews (3)
- Faraday Discussions (1)
- FASEB BioAdvances (1)
- FEBS Journal (4)
- FEBS Letters (1)
- FEBS Open Bio (1)
- FEMS Microbiology Reviews (3)
- Fly (1)
- Free Radical Biology & Medicine (1)
- Frontiers in Behavioral Neuroscience (2)
- Frontiers in Cell and Developmental Biology (12)
- Frontiers in Cellular and Infection Microbiology (4)
- Frontiers in Cellular Neuroscience (3)
- Frontiers in Chemistry (1)
- Frontiers in Endocrinology (2)
- Frontiers in Genetics (1)
- Frontiers in Immunology (35)
- Frontiers in Microbiology (6)
- Frontiers in Molecular Biosciences (2)
- Frontiers in Molecular Neuroscience (1)
- Frontiers in Neuroanatomy (1)
- Frontiers in Neurology (2)
- Frontiers in Neuroscience (1)
- Frontiers in Oncology (1)
- Frontiers in Physiology (2)
- Frontiers in Psychiatry (1)
- Frontiers in Psychology (1)
- Frontiers in Virology (1)
- Future Microbiology (1)
- Future Virology (1)
- G3 (1)
- G3: Genes, Genomes, Genetics (1)
- Gastroenterology (3)
- Gates Open Research (2)
- Gels (1)
- Genes (9)
- Genes & Development (6)
- Genes and Development (5)
- Genes and Diseases (1)
- Genetics (5)
- Genetics in Medicine (3)
- Genetics in Medicine Open (1)
- Genome Biology (6)
- Genome Medicine (3)
- Genome Research (4)
- Glia (3)
- Gut Microbes (1)
- Haematologica (3)
- Healthcare (1)
- Heart Rhythm (1)
- Heliyon (1)
- Heredity (1)
- HIV Medicine (1)
- Human Gene Therapy Methods (1)
- Human Molecular Genetics (3)
- Hypoxia (1)
- IJTLD OPEN (2)
- Immunity (27)
- Immunity and Ageing (1)
- Immunological Reviews (4)
- Immunology (2)
- Immunology Letters (1)
- Indian Journal of Ophthalmology (1)
- Infection and Immunity (3)
- Infectious Diseases and Therapy (1)
- Innate Immunity (1)
- Interface focus (4)
- International Journal for Parasitology (2)
- International Journal of Cancer (1)
- International Journal of Cardiology Heart & Vasculature (1)
- International Journal of Developmental Biology (1)
- International Journal of Environmental Research and Public Health (1)
- International Journal of Infectious Diseases (4)
- International Journal of Molecular Sciences (14)
- Investigative Ophthalmology and Visual Science (1)
- iScience (10)
- IUCrJ (3)
- JAMA Neurology (1)
- JAMA Psychiatry (1)
- JBMR Plus (1)
- JCI insight (7)
- JMIR Research Protocols (1)
- Journal for ImmunoTherapy of Cancer (1)
- Journal of Acquired Immune Deficiency Syndromes (5)
- Journal of Allergy and Clinical Immunology (4)
- Journal of Anatomy (12)
- Journal of Antimicrobial Chemotherapy (1)
- Journal of Autoimmunity (1)
- Journal of Biological Chemistry (9)
- Journal of Biological Education (1)
- Journal of Biological Methods (1)
- Journal of Biological Rhythms (1)
- Journal of Biophotonics (1)
- Journal of Cardiovascular Development and Disease (4)
- Journal of Cell Biology (16)
- Journal of Cell Science (71)
- Journal of Chemical Biology (1)
- Journal of Clinical Immunology (1)
- Journal of Clinical Investigation (11)
- Journal of Clinical Medicine (2)
- Journal of Clinical Microbiology (3)
- Journal of Clinical Oncology (1)
- Journal of Computational Biology (1)
- Journal of Critical Care (1)
- Journal of Crohns and Colitis (1)
- Journal of Developmental Biology (1)
- Journal of Experimental Biology (1)
- Journal of Experimental Medicine (34)
- Journal of Experimental Neuroscience (1)
- Journal of General Virology (1)
- Journal of Genetics and Genomics (1)
- Journal of Immunology (22)
- Journal of Immunology Research (1)
- Journal of Infection (3)
- Journal of Infectious Diseases (12)
- Journal of Inherited Metabolic Disease (1)
- Journal of Investigative Dermatology (1)
- Journal of Leukocyte Biology (3)
- Journal of Mathematical Biology (1)
- Journal of Medicinal Chemistry (11)
- Journal of Molecular Biology (5)
- Journal of molecular cell biology (1)
- Journal of Molecular Endocrinology (2)
- Journal of Molecular Graphics & Modelling (1)
- Journal of Neuro-Ophthalmology (1)
- Journal of Neurodevelopmental Disorders (1)
- Journal of Neuroinflammation (2)
- Journal of Neuroscience (3)
- Journal of Pathology (3)
- Journal of Physiology (1)
- Journal of Proteome Research (1)
- Journal of Psychopharmacology (1)
- Journal of Structural Biology (2)
- Journal of the American Chemical Society (1)
- Journal of the International AIDS Society (2)
- Journal of the National Cancer Institute (1)
- Journal of the Pediatric Infectious Diseases Society (1)
- Journal of the Royal Society Interface (3)
- Journal of Thoracic and Cardiovascular Surgery (1)
- Journal of Translational Autoimmunity (1)
- Journal of Virology (6)
- Journal of Visualized Experiments (8)
- Lab Animal (2)
- Laboratory Animals (10)
- Lancet Microbe (1)
- Leukemia (2)
- Life Science Alliance (17)
- Magnetic Resonance in Medicine (2)
- Malaria Journal (5)
- Mammalian Genome (1)
- Mathematical Biosciences and Engineering (1)
- mBio (16)
- Mechanisms of Development (2)
- Med (1)
- MedChemComm (1)
- Medical Image Analysis (1)
- Medicina (1)
- Metabolic Engineering (1)
- Metabolites (1)
- Methods (3)
- Methods and Protocols (1)
- Methods in Cell Biology (1)
- Methods in Enzymology (5)
- Methods in Molecular Biology (20)
- Microbes and Infection (2)
- Microbial Cell (5)
- Microbial Genomics (1)
- Microbiology (1)
- Microbiology Spectrum (2)
- MicroPublication Biology (2)
- Microscopy (1)
- Mobile DNA (1)
- Molecular & Cellular Oncology (1)
- Molecular and Cellular Biology (2)
- Molecular and Cellular Endocrinology (1)
- Molecular Biology and Evolution (5)
- Molecular Biology of the Cell (5)
- Molecular Cancer (1)
- Molecular Cancer Research (1)
- Molecular Cell (48)
- Molecular Genetics and Genomics (1)
- Molecular Genetics and Metabolism (1)
- Molecular Human Reproduction (1)
- Molecular Imaging (1)
- Molecular Immunology (1)
- Molecular Medicine (1)
- Molecular Metabolism (2)
- Molecular Microbiology (2)
- Molecular Neurodegeneration (1)
- Molecular Oncology (1)
- Molecular Psychiatry (5)
- Molecular Systems Biology (5)
- Molecular Therapy (1)
- Molecular Therapy - Oncolytics (1)
- Molecular Therapy : Nucleic Acids (1)
- mSphere (2)
- Mucosal Immunology (6)
- NAR Cancer (1)
- Natural Products and Bioprospecting (1)
- Nature (65)
- Nature Aging (2)
- Nature Biotechnology (5)
- Nature Cancer (8)
- Nature Cell Biology (25)
- Nature Communications (142)
- Nature Ecology and Evolution (2)
- Nature Genetics (8)
- Nature Immunology (20)
- Nature Materials (1)
- Nature Medicine (7)
- Nature Metabolism (3)
- Nature Methods (3)
- Nature Microbiology (10)
- Nature Neuroscience (4)
- Nature Physics (5)
- Nature Protocols (6)
- Nature Reviews Cancer (5)
- Nature Reviews Cardiology (1)
- Nature Reviews Clinical Oncology (1)
- Nature Reviews Drug Discovery (1)
- Nature Reviews Genetics (1)
- Nature Reviews Immunology (5)
- Nature Reviews Microbiology (2)
- Nature Reviews Molecular Cell Biology (8)
- Nature Reviews Nephrology (1)
- Nature Reviews Neurology (1)
- Nature Reviews Neuroscience (1)
- Nature Structural & Molecular Biology (4)
- Nature Structural and Molecular Biology (10)
- Neoplasia (1)
- Neuro-Oncology (1)
- Neurobiology of Disease (2)
- Neurobiology of Learning and Memory (1)
- NeuroImage (1)
- Neuron (3)
- Neuropathology and Applied Neurobiology (1)
- Neuroscience (1)
- New England Journal of Medicine (6)
- New Journal of Physics (1)
- New Scientist (1)
- NMR in Biomedicine (1)
- Notes and Records (1)
- Notes and Records of the Royal Society of London (1)
- Nuclear Medicine and Molecular Imaging (1)
- Nucleic Acids Research (21)
- Nutrients (1)
- Oncogene (7)
- Oncogenesis (1)
- Oncoimmunology (2)
- OncoTargets and Therapy (1)
- Open Biology (8)
- Open Forum Infectious Diseases (5)
- Ophthalmic Genetics (1)
- Paediatria Croatica (1)
- PAIN Reports (1)
- Parasitology International (1)
- Particle and Fibre Toxicology (1)
- Pathogens and Disease (1)
- Pediatric Allergy and Immunology (1)
- Pediatrics (2)
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- Philosophical Transactions of the Royal Society B: Biological Sciences (2)
- Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences (2)
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- PLOS ONE (35)
- PLOS Pathogens (32)
- PNAS Nexus (1)
- Proceedings of the 13th European Conference on Artificial Life, ECAL 2015 (1)
- Proceedings of the National Academy of Sciences of the United States of America (40)
- Proceedings of the National Academy of Sciences of USA (2)
- Proteomics (1)
- Reproduction Fertility and Development (1)
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- RNA Biology (1)
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- Scandinavian Journal of Immunology (1)
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- Scientific Reports (44)
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- Seminars in Immunopathology (1)
- Sexual Development (2)
- SLAS Technology (1)
- Small GTPases (1)
- Southern African Journal of HIV Medicine (2)
- Southern African Journal of Infectious Diseases (1)
- STAR Protocols (8)
- Stem Cell Reports (4)
- Stem Cell Research (6)
- Stem Cells (1)
- Stem Cells and Development (1)
- Structure (2)
- The CRISPR Journal (1)
- The EMBO Journal (18)
- The FASEB Journal (2)
- The FASEB journal : official publication of the Federation of American Societies for Experimental Biology (1)
- The International Journal of Developmental Biology (1)
- The Lancet (12)
- The Lancet HIV (2)
- The Lancet Infectious Diseases (6)
- The Lancet Microbe (5)
- The Lancet Oncology (2)
- The Lancet Psychiatry (1)
- The Lancet Regional Health - Europe (1)
- The Lancet Respiratory Medicine (3)
- The Neuroscientist (1)
- Therapeutic Advances in Ophthalmology (6)
- Therapeutic Advances in Rare Disease (1)
- Thorax (1)
- Traffic (6)
- Transcription (2)
- Translational Vision Science & Technology (1)
- Translational Vision Science and Technology (1)
- Trends in Biochemical Sciences (3)
- Trends in Cancer (3)
- Trends in Cell Biology (6)
- Trends in Genetics (1)
- Trends in Immunology (2)
- Trends in Microbiology (1)
- Trends in Molecular Medicine (1)
- Trends in Neurosciences (1)
- Trends in Parasitology (3)
- Trials (2)
- Tropical Medicine and International Health (1)
- Tuberculosis (6)
- Ultrasound in Obstetrics & Gynecology (1)
- Vaccine (4)
- Virulence (1)
- Viruses (2)
- Wellcome Open Research (38)
- Wiley Interdisciplinary Reviews. Developmental Biology (2)
- WIREs Mechanisms of Disease (1)
- World Journal for Pediatric & Congenital Heart Surgery (1)
- Yeast (1)
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Last updated : 03 March 2026 02:52