Publications

An intrinsically disordered region mediates RNA-binding selectivity and cellular activities of LARP6

Authors (12)

Federica Capraro
Giancarlo Abis
Alessio Incocciati
Peter J Simpson
Mehran Karimzadeh
Laura Masino
[...]
Tam TT Bui
Geoff Kelly
Hani Goodarzi
Maria R Conte
Faraz K Mardakheh

Nature Communications

Published 19 February 2026

Crick labs/ facilities

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An intrinsically disordered region mediates RNA-binding selectivity and pro-oncogenic activities of LARP6

Preprint

Authors (11)

Faraz Mardakheh
Federica Capraro
Giancarlo Abis
Alessio Incocciati
Mehran Karimzadeh
Laura Masino
Alexander Barley
Tam Bui
Geoff Kelly
Hani Goodarzi
Maria Conte

Research Square

Published 16 May 2025

Crick labs/ facilities

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Volatile anaesthetics modulate voltage-gated sodium channel
function at a site critical for gating

Preprint

Authors (7)

David Hollingworth
Karl F Herold
Geoff Kelly
Vitaliy B Mykhaylyk
Donghang Zhang
BA Wallace
Hugh C Hemmings Jr

bioRxiv

Published 4 November 2024

Crick labs/ facilities

MRC Biomedical NMR Centre

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NMR assignment of the conserved bacterial DNA replication protein DnaA domain IV

Authors (3)

Alexander Nguyen Abrams
Geoff Kelly
Julia Hubbard

Biomolecular NMR Assignments

Published 1 December 2024

Crick labs/ facilities

MRC Biomedical NMR Centre

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Structural basis for the rescue of hyperexcitable cells by the amyotrophic lateral sclerosis drug Riluzole

Authors (11)

David Hollingworth
Frances Thomas
Dana A Page
Mohamed A Fouda
Raquel Lopez-Rios De Castro
Altin Sula
Vitaliy B Mykhaylyk
Geoff Kelly
Martin B Ulmschneider
Peter C Ruben
BA Wallace

Nature Communications

Published 28 September 2024

Crick labs/ facilities

MRC Biomedical NMR Centre

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High-resolution magic angle spinning nuclear magnetic resonance spectroscopy of paired clinical liver tissue samples from hepatocellular cancer and surrounding region

Authors (15)

Wendy M Fernandes
Nicola Harris
Ane Zamalloa
Lissette Adofina
Parthi Srinivasan
Krishna Menon
[...]
James A Jarvis
Alain Oregioni
Shilpa Chokshi
Antonio Riva
I Jane Cox

International Journal of Molecular Sciences

Published 16 August 2024

Crick labs/ facilities

MRC Biomedical NMR Centre

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The Legionella collagen-like protein employs a distinct binding mechanism for the recognition of host glycosaminoglycans

Authors (18)

Saima Rehman
Anna Katarina Antonovic
Ian E McIntire
Huaixin Zheng
Leanne Cleaver
Maria Baczynska
[...]
Geoff Kelly
Christian D Lorenz
Arianna Fornili
Nicholas P Cianciotto
James A Garnett

Nature Communications

Published 8 June 2024

Crick labs/ facilities

MRC Biomedical NMR Centre

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Targeting the Plasmodium falciparum UCHL3 ubiquitin hydrolase using chemically constrained peptides

Authors (11)

Harry R King
Mark Bycroft
Thanh-Binh Nguyen
Geoff Kelly
Alexander A Vinogradov
Pamela JE Rowling
Katherine Stott
David B Ascher
Hiroaki Suga
Laura S Itzhaki
Katerina Artavanis-Tsakonas

Proceedings of the National Academy of Sciences of the United States of America

Published 21 May 2024

Crick labs/ facilities

MRC Biomedical NMR Centre

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Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis

Authors (10)

Nature Communications

Published 6 May 2024

Crick labs/ facilities

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The structural properties of full-length annexin A11

Authors (6)

Erika F Dudas
Mark D Tully
Tamas Foldes
Geoff Kelly
Gian Gaetano Tartaglia
Annalisa Pastore

Frontiers in Molecular Biosciences

Published 7 March 2024

Crick labs/ facilities

MRC Biomedical NMR Centre

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An intrinsically disordered region mediates RNA-binding selectivity and cellular activities of LARP6

An intrinsically disordered region mediates RNA-binding selectivity and pro-oncogenic activities of LARP6

Volatile anaesthetics modulate voltage-gated sodium channel
function at a site critical for gating

NMR assignment of the conserved bacterial DNA replication protein DnaA domain IV

Structural basis for the rescue of hyperexcitable cells by the amyotrophic lateral sclerosis drug Riluzole

High-resolution magic angle spinning nuclear magnetic resonance spectroscopy of paired clinical liver tissue samples from hepatocellular cancer and surrounding region

The Legionella collagen-like protein employs a distinct binding mechanism for the recognition of host glycosaminoglycans

Targeting the Plasmodium falciparum UCHL3 ubiquitin hydrolase using chemically constrained peptides

Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis

The structural properties of full-length annexin A11

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