DeBenedictis lab
Biodesign Laboratory
: Publications

Publications

Displaying 1 - 19 of 19

Last updated : 03 March 2026 03:24

Liquid liquid phase separation of the intrinsically disordered protein JPT2 compartmentalizes components of NAADP-evoked Ca2+ signaling

Preprint

Authors (10)

Sushil Kumar
Gihan S Gunaratne
Jasmine Cornish
Kirsten M Silvey
Qianru Mu
Zhong Guan
Gabriella T Heller
James T Slama
Sandip Patel
Jonathan S Marchant

bioRxiv

Published 11 January 2026

Crick labs/ facilities

Full details

Continuous evolution of a halogenase enzyme with improved solubility and activity for sustainable bioproduction

Preprint

Authors (11)

Andre Arashiro Pulschen
Justin Booth
Ari Satanowski
Christelle Soudy
Joaquin Caro-Astorga
Osaid Ather
Namita Patel
Ali Alidoust
Samir Aoudjane
Lily Nematollahi
Erika DeBenedictis

bioRxiv

Published 8 October 2025

Crick labs/ facilities

Full details

Results of the protein engineering tournament: An open science benchmark for protein modeling and design

Authors (12)

Chase Armer
Hassan Kane
Dana L Cortade
Henning Redestig
David A Estell
Adil Yusuf
[...]
Aviv Spinner
Debora Marks
TJ Brunette
Peter J Kelly
Erika DeBenedictis

Proteins: Structure, Function and Bioinformatics

Published 1 November 2025

Crick labs

Erika Alden DeBenedictis

Full details

How the past is shaping the future of life science: The influence of automation and AI on biology

Authors (3)

Carrie Cizauskas
Erika DeBenedictis
Pete Kelly

New Biotechnology

Published 25 September 2025

Crick labs

Erika Alden DeBenedictis

Full details

SubtiToolKit: a bioengineering kit for Bacillus subtilis and Gram-positive bacteria

Authors (7)

Joaquin Caro-Astorga
Matt Rogan
Koray Malcı
Hia Ming
Erika Debenedictis
Paul James
Tom Ellis

Trends in Biotechnology

Published 1 June 2025

Crick labs

Erika Alden DeBenedictis

Full details

Space synthetic biology: A paradigm for sustainability on earth and beyond

Authors (4)

Tiffany J Vora
Nils JH Averesch
Erika A DeBenedictis
Lynn J Rothschild

New Space

Published 1 December 2024

Crick labs

Erika Alden DeBenedictis

Full details

Micromolar fluoride contamination arising from glass NMR tubes and a simple solution for biomolecular applications

Authors (4)

Khushboo Matwani
Jasmine Cornish
Erika Alden DeBenedictis
Gabriella T Heller

Journal of Biomolecular NMR

Published 1 September 2024

Crick labs/ facilities

Full details

Polyextremophile engineering: a review of organisms that push the limits of life

Authors (10)

Joaquin Caro-Astorga
Joseph T Meyerowitz
Devon A Stork
Una Nattermann
Samantha Piszkiewicz
Lara Vimercati
Petra Schwendner
Antoine Hocher
Charles Cockell
Erika DeBenedictis

Frontiers in Microbiology

Published 5 June 2024

Crick labs

Erika Alden DeBenedictis

Full details

Five questions with Erika DeBenedictis

Authors (1)

Michael Francisco

Nature Biotechnology

Published 1 February 2024

Crick labs

Erika Alden DeBenedictis

Full details

A practical guide to phage- and robotics-assisted near-continuous evolution

Authors (5)

Samir Aoudjane
Stefan Golas
Osaid Ather
Michael J Hammerling
Erika DeBenedictis

Journal of Visualized Experiments

Published 12 January 2024

Crick labs

Erika Alden DeBenedictis

Full details

No assembly required: Time for stronger, simpler publishing standards for DNA sequences

Authors (3)

BW Thuronyi
Erika A DeBenedictis
Jeffrey E Barrick

PLOS Biology

Published 16 November 2023

Crick labs

Erika Alden DeBenedictis

Full details

The protein engineering tournament: An open science benchmark for protein modeling and design

Preprint

Authors (10)

Chase Armer
Hassan Kane
Dana Cortade
Dave Estell
Adil Yusuf
Radhakrishna Sanka
Henning Redestig
TJ Brunette
Pete Kelly
Erika DeBenedictis

arXiv

Published 18 September 2023

Crick labs

Erika Alden DeBenedictis

Full details

Support academic access to automated cloud labs to improve reproducibility

Authors (3)

Chase Armer
Florent Letronne
Erika DeBenedictis

PLOS Biology

Published 3 January 2023

Crick labs

Erika Alden DeBenedictis

Full details

Randomized gates eliminate bias in sort-seq assays

Authors (8)

Brian L Trippe
Buwei Huang
Erika A DeBenedictis
Brian Coventry
Nicholas Bhattacharya
Kevin K Yang
David Baker
Lorin Crawford

Protein Science

Published 1 September 2022

Crick labs

Erika Alden DeBenedictis

Full details

Measuring the tolerance of the genetic code to altered codon size

Authors (3)

Erika Alden DeBenedictis
Dieter Söll
Kevin M Esvelt

eLife

Published 16 March 2022

Crick labs

Erika Alden DeBenedictis

Full details

Systematic molecular evolution enables robust biomolecule discovery

Authors (6)

Erika A DeBenedictis
Emma J Chory
Dana W Gretton
Brian Wang
Stefan Golas
Kevin M Esvelt

Nature Methods

Published 1 January 2022

Crick labs

Erika Alden DeBenedictis

Full details

Multiplex suppression of four quadruplet codons via tRNA directed evolution

Authors (5)

Erika A DeBenedictis
Gavriela D Carver
Christina Z Chung
Dieter Söll
Ahmed H Badran

Nature Communications

Published 29 September 2021

Crick labs

Erika Alden DeBenedictis

Full details

Enabling high-throughput biology with flexible open-source automation

Authors (4)

Emma J Chory
Dana W Gretton
Erika A DeBenedictis
Kevin M Esvelt

Molecular Systems Biology

Published 1 March 2021

Crick labs

Erika Alden DeBenedictis

Full details

Daisy-chain gene drives for the alteration of local populations

Authors (10)

Charleston Noble
John Min
Jason Olejarz
Joanna Buchthal
Alejandro Chavez
Andrea L Smidler
Erika A DeBenedictis
George M Church
Martin A Nowak
Kevin M Esvelt

Proceedings of the National Academy of Sciences of the United States of America

Published 23 April 2019

Crick labs

Erika Alden DeBenedictis

Full details

Measuring the tolerance of the genetic code to altered codon size

Authors (3)

Erika Alden DeBenedictis
Dieter Söll
Kevin M Esvelt

eLife

Published 16 March 2022

Crick labs

Erika Alden DeBenedictis

Full details

Systematic molecular evolution enables robust biomolecule discovery

Authors (6)

Erika A DeBenedictis
Emma J Chory
Dana W Gretton
Brian Wang
Stefan Golas
Kevin M Esvelt

Nature Methods

Published 1 January 2022

Crick labs

Erika Alden DeBenedictis

Full details

Multiplex suppression of four quadruplet codons via tRNA directed evolution

Authors (5)

Erika A DeBenedictis
Gavriela D Carver
Christina Z Chung
Dieter Söll
Ahmed H Badran

Nature Communications

Published 29 September 2021

Crick labs

Erika Alden DeBenedictis

Full details

Enabling high-throughput biology with flexible open-source automation

Authors (4)

Emma J Chory
Dana W Gretton
Erika A DeBenedictis
Kevin M Esvelt

Molecular Systems Biology

Published 1 March 2021

Crick labs

Erika Alden DeBenedictis

Full details

Daisy-chain gene drives for the alteration of local populations

Authors (10)

Charleston Noble
John Min
Jason Olejarz
Joanna Buchthal
Alejandro Chavez
Andrea L Smidler
Erika A DeBenedictis
George M Church
Martin A Nowak
Kevin M Esvelt

Proceedings of the National Academy of Sciences of the United States of America

Published 23 April 2019

Crick labs

Erika Alden DeBenedictis

Full details

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Technical training

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DeBenedictis lab
Biodesign Laboratory
: Publications

Lab content

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Publications

Liquid liquid phase separation of the intrinsically disordered protein JPT2 compartmentalizes components of NAADP-evoked Ca2+ signaling

Continuous evolution of a halogenase enzyme with improved solubility and activity for sustainable bioproduction

Results of the protein engineering tournament: An open science benchmark for protein modeling and design

How the past is shaping the future of life science: The influence of automation and AI on biology

SubtiToolKit: a bioengineering kit for Bacillus subtilis and Gram-positive bacteria

Space synthetic biology: A paradigm for sustainability on earth and beyond

Micromolar fluoride contamination arising from glass NMR tubes and a simple solution for biomolecular applications

Polyextremophile engineering: a review of organisms that push the limits of life

Five questions with Erika DeBenedictis

A practical guide to phage- and robotics-assisted near-continuous evolution

No assembly required: Time for stronger, simpler publishing standards for DNA sequences

The protein engineering tournament: An open science benchmark for protein modeling and design

Support academic access to automated cloud labs to improve reproducibility

Randomized gates eliminate bias in sort-seq assays

Measuring the tolerance of the genetic code to altered codon size

Systematic molecular evolution enables robust biomolecule discovery

Multiplex suppression of four quadruplet codons via tRNA directed evolution

Enabling high-throughput biology with flexible open-source automation

Daisy-chain gene drives for the alteration of local populations

Measuring the tolerance of the genetic code to altered codon size

Systematic molecular evolution enables robust biomolecule discovery

Multiplex suppression of four quadruplet codons via tRNA directed evolution

Enabling high-throughput biology with flexible open-source automation

Daisy-chain gene drives for the alteration of local populations

The Francis Crick Institute is a unique partnership between

Research partnerships

Technical training

Free events for the public

About us

The Crick magazine

Lab content

Crick/Pre-Crick

Publications

Publications

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