Publications

Cell cycle regulation has shaped replication origins in budding yeast

Authors (10)

Chew Theng Lim
Thomas Miller
Kang Wei Tan
Saurabh Talele
Anne Early
Phil East
Humberto Sánchez
Nynke H Dekker
Alessandro Costa
John Diffley

Nature Structural & Molecular Biology

Published 1 September 2025

Crick labs/ facilities

Full details

An archaeal nucleoid-associated protein binds an essential motif in DNA replication origins

Authors (6)

Rajkumar Dhanaraju
Rachel Y Samson
Xu Feng
Alessandro Costa
Giovanni Gonzalez-Gutierrez
Stephen D Bell

Nature Communications

Published 5 June 2025

Crick labs

Alessandro Costa

Full details

How similar are the molecular mechanisms of yeast and metazoan genome replication initiation?

Authors (2)

Giacomo Palm
Alessandro Costa

Biochemical Society Transactions

Published 1 April 2025

Crick labs

Alessandro Costa

Full details

EMD-51398: OCCM maturation intermediate stalled with an Arginine Finger mutation in Mcm5: Conformer 2. Consensus map

Authors (2)

Alessandro Costa
Agata Butryn

Electron Microscopy Data Bank (EMDB)

Published 5 March 2025

Crick labs

Alessandro Costa

Full details

EMD-51399: OCCM maturation intermediate stalled with an Arginine Finger mutation in Mcm5: Conformer 2. ORC local refinement

Authors (3)

A Butryn
Alessandro Costa
Julia Greiwe

Electron Microscopy Data Bank (EMDB)

Published 5 March 2025

Crick labs

Alessandro Costa

Full details

EMD-51400: OCCM maturation intermediate stalled with an Arginine Finger mutation in Mcm5: Conformer 2. Local MCM-Cdt1 refinement

Authors (2)

A Butryn
Alessandro Costa

Electron Microscopy Data Bank (EMDB)

Published 5 March 2025

Crick labs

Alessandro Costa

Full details

EMD-51401: OCCM maturation intermediate stalled with an Arginine Finger mutation in Mcm5: Conformer 2. Composite map

Authors (2)

Allessandro Costa
A Butryn

Electron Microscopy Data Bank (EMDB)

Published 5 March 2025

Crick labs

Alessandro Costa

Full details

EMD-51404: OCCM maturation intermediate stalled with an Arginine Finger mutation in Mcm2. Consensus map

Authors (2)

Alessandro Costa
A Butryn

Electron Microscopy Data Bank (EMDB)

Published 5 March 2025

Crick labs

Alessandro Costa

Full details

EMD-51406: OCCM maturation intermediate stalled with an Arginine Finger mutation in Mcm2. MCM-Cdt1 local refinement

Authors (2)

Alessandro Costa
A Butryn

Electron Microscopy Data Bank (EMDB)

Published 5 March 2025

Crick labs

Alessandro Costa

Full details

EMD-51407: OCCM maturation intermediate stalled with an Arginine Finger mutation in Mcm2. Composite map

Authors (2)

Alessandro Costa
A Butryn

Electron Microscopy Data Bank (EMDB)

Published 5 March 2025

Crick labs

Alessandro Costa

Full details

EMD-51441: OCCM maturation intermediate stalled with an Arginine Finger mutation in Mcm5: Conformer 1

Authors (2)

A Butryn
A Costa

Electron Microscopy Data Bank (EMDB)

Published 5 March 2025

Crick labs

Alessandro Costa

Full details

PDB Entry - 9GJP (pdb_00009gjp): OCCM maturation intermediate stalled with an Arginine Finger mutation in Mcm5: Conformer 2

Authors (2)

A Butryn
Alessandro Costa

Protein Data Bank (RCSB PDB)

Published 5 March 2025

Crick labs

Alessandro Costa

Full details

PDB Entry - 9GJW (pdb_00009gjw): OCCM maturation intermediate stalled with an Arginine Finger mutation in Mcm2

Authors (2)

A Butryn
Alessandro Costa

Protein Data Bank (RCSB PDB)

Published 5 March 2025

Crick labs

Alessandro Costa

Full details

PDB Entry - 9GM5 (pdb_00009gm5): OCCM maturation intermediate stalled with an Arginine Finger mutation in Mcm5: Conformer 1

Authors (1)

Alessandro Costa

Protein Data Bank (RCSB PDB)

Published 5 March 2025

Crick labs

Alessandro Costa

Full details

Unidirectional MCM translocation away from ORC drives origin licensing

Authors (3)

Nature Communications

Published 17 January 2025

Crick labs/ facilities

Full details

MCM double hexamer loading visualized with human proteins

Authors (8)

Nature

Published 12 December 2024

Crick labs/ facilities

Full details

EMDB entry EMD-19618: H. sapiens MCM2-7 double hexamer bound to double stranded DNA

Authors (4)

Electron Microscopy Data Bank (EMDB)

Published 2 October 2024

Crick labs/ facilities

Full details

EMDB entry EMD-19619: H. sapiens MCM2-7 hexamer bound to double stranded DNA

Authors (4)

Electron Microscopy Data Bank (EMDB)

Published 2 October 2024

Crick labs/ facilities

Full details

EMDB entry EMD-19620: H. sapiens MCM bound to double stranded DNA and ORC6 as part of the MCM-ORC complex

Authors (4)

Electron Microscopy Data Bank (EMDB)

Published 2 October 2024

Crick labs/ facilities

Full details

EMDB entry EMD-19621: H. sapiens ORC1-5 bound to double stranded DNA as part of the MCM-ORC complex

Authors (4)

Electron Microscopy Data Bank (EMDB)

Published 2 October 2024

Crick labs/ facilities

Full details

Research partnerships

Technical training

Free events for the public

About us

The Crick magazine

Costa lab
Macromolecular Machines Laboratory
: Publications

Lab content

Publications

Year published

Research topics

Crick/Pre-Crick

Publication type

Journal

Cell cycle regulation has shaped replication origins in budding yeast

An archaeal nucleoid-associated protein binds an essential motif in DNA replication origins

How similar are the molecular mechanisms of yeast and metazoan genome replication initiation?

EMD-51398: OCCM maturation intermediate stalled with an Arginine Finger mutation in Mcm5: Conformer 2. Consensus map

EMD-51399: OCCM maturation intermediate stalled with an Arginine Finger mutation in Mcm5: Conformer 2. ORC local refinement

EMD-51400: OCCM maturation intermediate stalled with an Arginine Finger mutation in Mcm5: Conformer 2. Local MCM-Cdt1 refinement

EMD-51401: OCCM maturation intermediate stalled with an Arginine Finger mutation in Mcm5: Conformer 2. Composite map

EMD-51404: OCCM maturation intermediate stalled with an Arginine Finger mutation in Mcm2. Consensus map

EMD-51406: OCCM maturation intermediate stalled with an Arginine Finger mutation in Mcm2. MCM-Cdt1 local refinement

EMD-51407: OCCM maturation intermediate stalled with an Arginine Finger mutation in Mcm2. Composite map

EMD-51441: OCCM maturation intermediate stalled with an Arginine Finger mutation in Mcm5: Conformer 1

PDB Entry - 9GJP (pdb_00009gjp): OCCM maturation intermediate stalled with an Arginine Finger mutation in Mcm5: Conformer 2

PDB Entry - 9GJW (pdb_00009gjw): OCCM maturation intermediate stalled with an Arginine Finger mutation in Mcm2

PDB Entry - 9GM5 (pdb_00009gm5): OCCM maturation intermediate stalled with an Arginine Finger mutation in Mcm5: Conformer 1

Unidirectional MCM translocation away from ORC drives origin licensing

MCM double hexamer loading visualized with human proteins

EMDB entry EMD-19618: H. sapiens MCM2-7 double hexamer bound to double stranded DNA

EMDB entry EMD-19619: H. sapiens MCM2-7 hexamer bound to double stranded DNA

EMDB entry EMD-19620: H. sapiens MCM bound to double stranded DNA and ORC6 as part of the MCM-ORC complex

EMDB entry EMD-19621: H. sapiens ORC1-5 bound to double stranded DNA as part of the MCM-ORC complex

The Francis Crick Institute is a unique partnership between

Research partnerships

Technical training

Free events for the public

About us

The Crick magazine

Lab content

Publications

Year published

Research topics

Crick/Pre-Crick

Publication type

Journal

Publications

Share the page

The Francis Crick Institute is a unique partnership between