Publications

A circadian checkpoint relocates neutrophils to minimize injury

Authors (23)

Alejandra Aroca-Crevillén
Sandra Martín-Salamanca
Lidiane S Torres
Georgiana Crainiciuc
Jon Sicilia
Eduardo Peñaloza-Martínez
[...]
José T Ortiz-Pérez
María Ángeles Moro
Héctor Bueno
Gerry AF Nicolaes
Andrés Hidalgo

Journal of Experimental Medicine

Published 2 February 2026

Crick labs

Jose Adrover

Full details

Diurnally-regulated corticosterone and melatonin inversely control endotoxin-induced acute immune responses

Authors (22)

Montaser Haddad
Sebastien Trzebanski
Ramon Bossardi Ramos
Lizeth-Alejandra Ordonez Moreno
Allison Rahtes
Eman Khatib-Massalha
[...]
Martin Schlegel
Steffen Jung
Tsvee Lapidot
Jose M. Adrover
Orit Kollet

European Journal of Immunology

Published 1 November 2025

Crick labs

Jose Adrover

Full details

Systematic analysis of immune cell motility leveraging the open intravital microscopy database Immunemap

Authors (14)

Diego Ulisse Pizzagalli
Pau Carrillo-Barberà
Himanshu Bansal
Elisa Palladino
Kevin Ceni
Benedikt Thelen
[...]
Johannes Textor
Inge MN Wortel
Immunemap Consortium
Rolf Krause
Santiago Fernandez Gonzalez

EMBO Journal

Published 2 January 2026

Crick labs

Jose Adrover

Full details

Heart of the matter: Neutrophils, cancer, and cardiovascular disease

Authors (4)

Saira Ambreen
Afshan Mccarthy
Andrés Hidalgo
Jose M. Adrover

Journal of Experimental Medicine

Published 1 September 2025

Crick labs

Jose Adrover

Full details

Neutrophils drive vascular occlusion, tumour necrosis and metastasis

Authors (14)

Jose M. Adrover
Xiao Han
Lijuan Sun
Takeo Fujii
Nicole Sivetz
Juliane Daßler-Plenker
[...]
Courtney D Cannon
Won Jin Ho
George Raptis
R Scott Powers
Mikala Egeblad

Nature

Published 11 September 2025

Crick labs

Jose Adrover

Full details

Targeting neutrophil extracellular traps to inhibit colon cancer tumor necrosis and metastasis

Preprint

Authors (23)

E Gazzara
Jose M. Adrover
A Lui
S Han
Z Aminzada
N Bhandari
[...]
DA Tuveson
S Beyaz
PMK Westcott
M Egeblad
S Gholami

bioRxiv

Published 3 June 2025

Crick labs

Jose Adrover

Full details

Chronic stress increases metastasis via neutrophil-mediated changes to the microenvironment

Authors (20)

Xue-Yan He
Yuan Gao
David Ng
Evdokia Michalopoulou
Shanu George
Jose M. Adrover
[...]
Chang Su
David L Spector
Christopher R Vakoc
Linda Van Aelst
Mikala Egeblad

Cancer Cell

Published 11 March 2024

Crick labs

Jose Adrover

Full details

NETworking with cancer: The bidirectional interplay between cancer and neutrophil extracellular traps

Authors (5)

Jose M. Adrover
Sheri AC McDowell
Xue-Yan He
Daniela F Quail
Mikala Egeblad

Cancer Cell

Published 13 March 2023

Crick labs

Jose Adrover

Full details

Senescence rewires microenvironment sensing to facilitate antitumor immunity

Authors (20)

Hsuan-An Chen
Yu-Jui Ho
Riccardo Mezzadra
Jose M. Adrover
Ryan Smolkin
Changyu Zhu
[...]
Ronald C Hendrickson
Mikala Egeblad
Zhenghao Chen
Direna Alonso-Curbelo
Scott W Lowe

Cancer Discovery

Published 1 February 2023

Crick labs

Jose Adrover

Full details

PTP1B inhibitors protect against acute lung injury and regulate CXCR4 signaling in neutrophils

Authors (11)

Dongyan Song
Jose M. Adrover
Christy Felice
Lisa N Christensen
Xue-Yan He
Joseph R Merrill
John E Wilkinson
Tobias Janowitz
Scott K Lyons
Mikala Egeblad
Nicholas K Tonks

JCI insight

Published 22 July 2022

Crick labs

Jose Adrover

Full details

In vivo imaging of circadian NET formation during lung injury by four-dimensional intravital microscopy

Authors (3)

Alejandra Aroca-Crevillén
Andres Hidalgo
Jose M. Adrover

Methods in Molecular Biology

Published 25 May 2022

Crick labs

Jose Adrover

Full details

Measuring circadian neutrophil infiltration in tissues by paired whole-mount tissue clearing and flow cytometry

Authors (3)

Tommaso Vicanolo
Andres Hidalgo
Jose M. Adrover

Methods in Molecular Biology

Published 25 May 2022

Crick labs

Jose Adrover

Full details

Disulfiram inhibits neutrophil extracellular trap formation and protects rodents from acute lung injury and SARS-CoV-2 infection

Authors (13)

Jose M. Adrover
Lucia Carrau
Juliane Daßler-Plenker
Yaron Bram
Vasuretha Chandar
Sean Houghton
[...]
Margaret Shevik
Benjamin R tenOever
Scott K Lyons
Robert E Schwartz
Mikala Egeblad

JCI insight

Published 8 March 2022

Crick labs

Jose Adrover

Full details

Behavioural immune landscapes of inflammation

Authors (28)

Georgiana Crainiciuc
Miguel Palomino-Segura
Miguel Molina-Moreno
Jon Sicilia
David G Aragones
Jackson Liang Yao Li
[...]
Lai Guan Ng
Gabriel F Calvo
Iván González-Díaz
Fernando Díaz-de-María
Andrés Hidalgo

Nature

Published 20 January 2022

Crick labs

Jose Adrover

Full details

Longitudinal intravital imaging through clear silicone windows

Authors (11)

Laura Maiorino
Margaret Shevik
Jose M. Adrover
Xiao Han
Elias Georgas
John Erby Wilkinson
Harrison Seidner
Leonie Foerschner
David A Tuveson
Yi-Xian Qin
Mikala Egeblad

Journal of Visualized Experiments

Published 5 January 2022

Crick labs

Jose Adrover

Full details

Co-option of neutrophil fates by tissue environments

Authors (33)

Iván Ballesteros
Andrea Rubio-Ponce
Marco Genua
Eleonora Lusito
Immanuel Kwok
Gabriel Fernández-Calvo
[...]
Christoph Reinhardt
Irina A Udalova
Lai Guan Ng
Renato Ostuni
Andrés Hidalgo

Cell

Published 25 November 2020

Crick labs

Jose Adrover

Full details

Thrombo-tag, an in vivo formed nanotracer for the detection of thrombi in mice by fast pre-targeted molecular imaging

Authors (7)

Jose M. Adrover
Juan Pellico
Irene Fernández-Barahona
Sandra Martín-Salamanca
Jesús Ruiz-Cabello
Andrés Hidalgo
Fernando Herranz

Nanoscale

Published 7 December 2020

Crick labs

Jose Adrover

Full details

Targeting potential drivers of COVID-19: Neutrophil extracellular traps

Authors (23)

Betsy J Barnes
Jose M. Adrover
Amelia Baxter-Stoltzfus
Alain Borczuk
Jonathan Cools-Lartigue
James M Crawford
[...]
Jonathan D Spicer
Christian C Yost
Andrew Weber
Yu Zuo
Mikala Egeblad

Journal of Experimental Medicine

Published 1 June 2020

Crick labs

Jose Adrover

Full details

Circadian features of neutrophil biology

Authors (3)

Alejandra Aroca-Crevillén
Jose M. Adrover
Andrés Hidalgo

Frontiers in Immunology

Published 3 April 2020

Crick labs

Jose Adrover

Full details

Programmed 'disarming' of the neutrophil proteome reduces the magnitude of inflammation

Authors (17)

Jose M. Adrover
Alejandra Aroca-Crevillén
Georgiana Crainiciuc
Fernando Ostos
Yeny Rojas-Vega
Andrea Rubio-Ponce
[...]
Ignacio Lizasoaín
Antoni Torres
Jesús Ruiz-Cabello
Jesús Vázquez
Andrés Hidalgo

Nature Immunology

Published 1 February 2020

Crick labs

Jose Adrover

Full details

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A circadian checkpoint relocates neutrophils to minimize injury

Diurnally-regulated corticosterone and melatonin inversely control endotoxin-induced acute immune responses

Systematic analysis of immune cell motility leveraging the open intravital microscopy database Immunemap

Heart of the matter: Neutrophils, cancer, and cardiovascular disease

Neutrophils drive vascular occlusion, tumour necrosis and metastasis

Targeting neutrophil extracellular traps to inhibit colon cancer tumor necrosis and metastasis

Chronic stress increases metastasis via neutrophil-mediated changes to the microenvironment

NETworking with cancer: The bidirectional interplay between cancer and neutrophil extracellular traps

Senescence rewires microenvironment sensing to facilitate antitumor immunity

PTP1B inhibitors protect against acute lung injury and regulate CXCR4 signaling in neutrophils

In vivo imaging of circadian NET formation during lung injury by four-dimensional intravital microscopy

Measuring circadian neutrophil infiltration in tissues by paired whole-mount tissue clearing and flow cytometry

Disulfiram inhibits neutrophil extracellular trap formation and protects rodents from acute lung injury and SARS-CoV-2 infection

Behavioural immune landscapes of inflammation

Longitudinal intravital imaging through clear silicone windows

Co-option of neutrophil fates by tissue environments

Thrombo-tag, an in vivo formed nanotracer for the detection of thrombi in mice by fast pre-targeted molecular imaging

Targeting potential drivers of COVID-19: Neutrophil extracellular traps

Circadian features of neutrophil biology

Programmed 'disarming' of the neutrophil proteome reduces the magnitude of inflammation

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