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Structure of V1H

Researchers discover how cells raise the alarm when damaged or infected

Our cells need acidic compartments for digestion and recycling of nutrients. Acid is pumped in by a complex assembly of proteins called the V-ATPase. But what happens when our cells get damaged? The acid leaks out and the cell has to respond. Researchers at the Crick discovered how the V-ATPase proton pump itself sounds the alarm: one protein in the complex recruits a crucial part of the self-eating (autophagy) machinery. They think this is especially important during infection since some bacteria target this pathway, and many viruses like influenza trigger it.

The V-ATPase/ATG16L1 axis is controlled by the V1H subunit

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Published in Molecular Cell

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