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Researchers at the Crick are tackling the big questions about human health and disease, and new findings are published every week.

Our faculty have picked some of the most significant papers published by Crick scientists, all of which are freely available thanks to our open science policy.

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Molecular key in transporting important dietary fats to fetus during pregnancy identified

Researchers at the Crick and King's College London have outlined a new mechanism in mice for transporting long-chain polyunsaturated fatty acids, like omega-3s, from the mother to the fetus during pregnancy. The team found that LC-PUFA stores in the mother are transported to the fetus in carrier molecules called lipoproteins.

As humans, we can’t create our own LC-PUFAs, and so we must acquire them through our diets. LC-PUFA deficiency during pregnancy can lead to a number of complications, including stillbirth, fetal growth problems and an increased chance of neurodevelopmental problems in the child. These results could help to identify ways to tackle LC-PUFA deficiency in the developing fetus.

A co-ordinated transcriptional programme in the maternal liver supplies long chain polyunsaturated fatty acids to the conceptus using phospholipids

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Published in Nature Communications

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Research case studies 

Explore a selection of recent case studies that spotlight particular areas of research at the Crick.