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Explore a selection of research case studies from the past five years.

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Researchers at the Crick are tackling the big questions about human health and disease, and new findings are published every week.

Our faculty have picked some of the most significant papers published by Crick scientists, all of which are freely available thanks to our open science policy.

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Understanding and harnessing a deadly mimic

The Salmonella protein SteE forcibly reprogrammes the eukaryotic kinase GSK3 so it acts on a new set of substrates that benefit Salmonella virulence. Kinase reprogramming depends on several short linear motifs in SteE that trick GSK3 into recognising SteE as a 'normal' cellular signalling partner. Researchers at the Crick have shown how each motif contributes to manipulating GSK3, and revealed the existence of SteE-like proteins in other bacterial pathogens. This work will aid the rational design of synthetic reprogramming proteins.

Bacterial effectors mediate kinase reprogramming through mimicry of conserved eukaryotic motifs

Published in EMBO Reports

Published

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Research case studies 

Explore a selection of recent case studies that spotlight particular areas of research at the Crick.