Publication highlights

Go inside our research

Explore a selection of research case studies from the past five years.

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Researchers at the Crick are tackling the big questions about human health and disease, and new findings are published every week.

Our faculty have picked some of the most significant papers published by Crick scientists, all of which are freely available thanks to our open science policy.

New insights into HIV infection

A study from the Bishop lab has looked into HIV-1 uncoating, the process by which the viral core breaks down during infection. Their work suggests that uncoating or remodelling of the HIV-1 capsid lattice occurs at the nuclear pore, and that this step is essential for a productive infection.

HIV-1 requires capsid remodelling at the nuclear pore for nuclear entry and integration

Published in PLOS Pathogens

Published

Phospho-dependent regulation of SAMHD1 oligomerisation couples catalysis and restriction

This study explained the mechanism of SAMHD1 regulation by phosphorylation/tetramerisation and correlated restriction activity with the capacity of SAMHD1 to form long lived, stable tetramers. These data form the basis of the prevailing model for SAMHD1 restriction of HIV-1 where dNTP-stabilised SAMHD1 tetramers deplete and maintain low levels of dNTPs in the non-permissive cells resistant to HIV-1 infection.

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Published in PLOS Pathogens

Published

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Research case studies 

Explore a selection of recent case studies that spotlight particular areas of research at the Crick.