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Explore a selection of research case studies from the past five years.

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Researchers at the Crick are tackling the big questions about human health and disease, and new findings are published every week.

Our faculty have picked some of the most significant papers published by Crick scientists, all of which are freely available thanks to our open science policy.

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Protein coats around vesicles

Understanding coated vesicle formation in vitro

Secretory proteins are transported across the cell via membrane vesicles to perform essential functions such as nutrient uptake, cell-cell communication, tissue development, and more. These vesicles are generated through the concerted action of a set of proteins that assemble to form a ‘coat’ around them. Revealing how the coat assembles and how it interacts with the cargo proteins to be transported is essential to understand the inner workings of our cells, and why disease ensues when this process goes wrong. Here, researchers at the Crick reconstituted coated vesicle formation in vitro from native cell membranes and analysed its architecture using advanced electron microscopy techniques.

Cryo-electron tomography reveals how COPII assembles on cargo-containing membranes

Published in Nature Structural and Molecular Biology

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Research case studies 

Explore a selection of recent case studies that spotlight particular areas of research at the Crick.