Nicola Cook

Integrase anchors viral RNA to the HIV-1 capsid interior

Authors (19)

Matthew Singer
Zhen Li
Juan S Rey
Joshua Hope
Florian Chenavier
Nicola Cook
[...]
Giulia Zanetti
Peijun Zhang
Juan R Perilla
Alan N Engelman
Peter Cherepanov

Nature

Published 18 February 2026

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Multiplexed detection of viral antigen and RNA using nanopore sensing and encoded molecular probes

Authors (26)

Ren Ren
Shenglin Cai
Xiaona Fang
Xiaoyi Wang
Zheng Zhang
Micol Damiani
[...]
Zhaofeng Luo
Weihong Tan
Yuri Korchev
Aleksandar P Ivanov
Joshua B Edel

Nature Communications

Published 14 November 2023

Crick labs

Peter Cherepanov

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SARS-CoV-2 antibody responses associate with sex, age and disease severity in previously uninfected people admitted to hospital with COVID-19: An ISARIC4C prospective study

Authors (29)

Eleanor Parker
Jordan Thomas
Kelly J Roper
Samreen Ijaz
Tansy Edwards
Federica Marchesin
[...]
Malcolm G Semple
William A Paxton
Richard S Tedder
Georgios Pollakis
ISARIC4C Investigators

Frontiers in Immunology

Published 15 March 2023

Crick labs

Peter Cherepanov

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The drug-induced interface that drives HIV-1 integrase hypermultimerization and loss of function

Authors (15)

Matthew Singer
Tung Dinh
Lev Levintov
Arun S Annamalai
Juan S Rey
Lorenzo Briganti
[...]
Alan N Engelman
Baek Kim
Juan R Perilla
Mamuka Kvaratskhelia
Peter Cherepanov

mBio

Published 1 February 2023

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PDB entry 8A1P: HIV-1 Integrase Catalytic Core Domain and C-Terminal Domain in Complex with Allosteric Integrase Inhibitor BI-D

Authors (4)

Matthew Singer
Val Pye
Nicola Cook
Peter Cherepanov

Protein Data Bank (RCSB PDB)

Published 1 February 2023

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PDB entry 8A1Q: HIV-1 Integrase Catalytic Core Domain and C-Terminal Domain in Complex with Allosteric Integrase Inhibitor STP0404 (Pirmitegravir)

Authors (4)

Matthew Singer
Val Pye
Nicola Cook
Peter Cherepanov

Protein Data Bank (RCSB PDB)

Published 1 February 2023

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Mapping of SARS-CoV-2 IgM and IgG in gingival crevicular fluid: antibody dynamics and linkage to severity of COVID-19 in hospital inpatients

Authors (20)

Samreen Ijaz
Steve Dicks
Keerthana Jegatheesan
Eleanor Parker
Ksenia Katsanovskaja
Elen Vink
[...]
Peter JM Openshaw
J Kenneth Baillie
Malcolm G Semple
Richard S Tedder
for ISARIC4C Investigators

Journal of Infection

Published 1 August 2022

Crick labs

Peter Cherepanov

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Multivalent interactions essential for lentiviral integrase function

Authors (20)

Allison Ballandras-Colas
Vidya Chivukula
Dominika Gruszka
Zelin Shan
Parmit K Singh
Val Pye
[...]
Ian Taylor
Dmitry Lyumkis
Hasan Yardimci
Alan N Engelman
Peter Cherepanov

Nature Communications

Published 3 May 2022

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SARS-CoV-2 can recruit a haem metabolite to evade antibody immunity

Authors (40)

Annachiara Rosa
Val Pye
Carl Graham
Luke Muir
Jeffrey Seow
Kevin Ng
[...]
Richard S Tedder
George Kassiotis
Laura E Mccoy
Katie J Doores
Peter Cherepanov

Science advances

Published 28 May 2021

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Structural basis of second-generation HIV integrase inhibitor action and viral resistance

Authors (10)

Nicola Cook
Wen Li
Dénes Berta
Magd Badaoui
Allison Ballandras-Colas
Andrea Nans
Abhay Kotecha
Edina Rosta
Alan N Engelman
Peter Cherepanov

Science

Published 14 February 2020

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Differential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6

Authors (8)

Sooin Jang
Nicola Cook
Val Pye
Gregory J Bedwell
Amanda M Dudek
Parmit K Singh
Peter Cherepanov
Alan N Engelman

Nucleic Acids Research

Published 21 May 2019

Crick labs

Peter Cherepanov

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A supramolecular assembly mediates lentiviral DNA integration

Authors (14)

Allison Ballandras-Colas
Daniel P Maskell
Erik Serrao
Julia Locke
Paolo Swuec
Stefán R Jónsson
[...]
Ian Taylor
Valgerdur Andrésdóttir
Alan N Engelman
Alessandro Costa
Peter Cherepanov

Science

Published 6 January 2017

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Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function

Authors (8)

Allison Ballandras-Colas
Monica Brown
Nicola Cook
Tamaria G Dewdney
Borries Demeler
Peter Cherepanov
Dmitry Lyumkis
Alan N Engelman

Nature

Published 18 February 2016

Crick labs

Peter Cherepanov

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Structural basis for nuclear import of splicing factors by human Transportin 3

Authors (14)

Goedele N Maertens
Nicola Cook
Weifeng Wang
Stephen Hare
Saumya Shree Gupta
Ilker Öztop
[...]
Bram Snijders
Vineet N KewalRamani
Ariberto Fassati
Alan Engelman
Peter Cherepanov

Proceedings of the National Academy of Sciences of the United States of America

Published 18 February 2014

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Integrase anchors viral RNA to the HIV-1 capsid interior

Multiplexed detection of viral antigen and RNA using nanopore sensing and encoded molecular probes

SARS-CoV-2 antibody responses associate with sex, age and disease severity in previously uninfected people admitted to hospital with COVID-19: An ISARIC4C prospective study

The drug-induced interface that drives HIV-1 integrase hypermultimerization and loss of function

PDB entry 8A1P: HIV-1 Integrase Catalytic Core Domain and C-Terminal Domain in Complex with Allosteric Integrase Inhibitor BI-D

PDB entry 8A1Q: HIV-1 Integrase Catalytic Core Domain and C-Terminal Domain in Complex with Allosteric Integrase Inhibitor STP0404 (Pirmitegravir)

Mapping of SARS-CoV-2 IgM and IgG in gingival crevicular fluid: antibody dynamics and linkage to severity of COVID-19 in hospital inpatients

Multivalent interactions essential for lentiviral integrase function

SARS-CoV-2 can recruit a haem metabolite to evade antibody immunity

Structural basis of second-generation HIV integrase inhibitor action and viral resistance

Differential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6

A supramolecular assembly mediates lentiviral DNA integration

Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function

Structural basis for nuclear import of splicing factors by human Transportin 3

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