Karine Rizzoti

Microglia Rank signaling regulates GnRH function and the Hypothalamic-Pituitary-Gonadal axis

Preprint

Authors (23)

Alejandro Collado-Sole
Nozha Borjini
Jing Zhai
Gonzalo Soria-Alcaide
Cintia Folgueira
Francisco Ruiz-Pino
[...]
Alberto Pascual Bravo
Rafael Fernández-Chacón
Manuel Tena-Sempere
Nelly Pitteloud
Eva Gonzalez-Suarez

bioRxiv

Published 18 February 2026

Crick labs

Robin Lovell-Badge

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Modeling the chondrocyte-derived osteoblasts formation process reveals its molecular signature and regulation network

Authors (24)

Raquel Ruiz-Hernández
Laurie Gay
Veronica Moncho Amor
Pablo Martín
Jhonatan A Vergara-Arce
Stefania Di Blasio
[...]
Karine Rizzoti
Robin Lovell-Badge
Dominique Bonnet
Ilaria Malanchi
Ander Abarrategi

Bone Research

Published 9 February 2026

Crick labs/ facilities

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The chordoid glioma PRKCA D463H mutation is a kinase inactive, gain-of-function allele that induces early-onset chondrosarcoma in mice

Authors (15)

Veronique Calleja
Jack C Henry
Mathias Cobbaut
Joanne Sewell
Karine Rizzoti
Francesca Houghton
[...]
Alejandro Suárez-Bonnet
Simon L Priestnall
Neil McDonald
Angus JM Cameron
Peter Parker

Science Signaling

Published 4 November 2025

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Gonadotrophs have a dual origin, with most derived from early postnatal pituitary stem cells

Authors (12)

Daniel Sheridan
Probir Chakravarty
Gil Golan
Yiolanda Shiakola
Jessica Olsen
Elise Burnett
[...]
Tatiana Fiordelisio
Patrice Mollard
Philippa Melamed
Robin Lovell-Badge
Karine Rizzoti

Nature Communications

Published 21 May 2025

Crick labs/ facilities

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Hypopituitarism in Sox3 null mutants correlates with altered NG2-glia in the median eminence and is influenced by aspirin and gut microbiota

Authors (3)

PLOS Genetics

Published 26 September 2024

Crick labs/ facilities

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GEO entry GSE217648: SOX9-positive pituitary stem cells differ according to their position in the gland and maintenance of their progeny depends on context

Authors (3)

Probir Chakravarty
Karine Rizzoti
Robin Lovell-Badge

Gene Expression Omnibus (GEO)

Published 12 October 2023

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SOX9-positive pituitary stem cells differ according to their position in the gland and maintenance of their progeny depends on context

Authors (4)

Karine Rizzoti
Probir Chakravarty
Daniel Sheridan
Robin Lovell-Badge

Science advances

Published 4 October 2023

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Neural plate progenitors give rise to both anterior and posterior pituitary cells

Authors (8)

Qiyu Chen
Dena Leshkowitz
Hanjie Li
Andreas van Impel
Stefan Schulte-Merker
Ido Amit
Karine Rizzoti
Gil Levkowitz

Developmental Cell

Published 4 December 2023

Crick labs

Robin Lovell-Badge

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Novel candidate regulators and developmental trajectory of pituitary thyrotropes

Authors (15)

Leonard YM Cheung
Lucy Menage
Karine Rizzoti
Greg Hamilton
Typhanie Dumontet
Kaitlin Basham
[...]
John Cobb
Alessio Delogu
Robin Lovell-Badge
Gary D Hammer
Sally A Camper

Endocrinology

Published 1 June 2023

Crick labs

Robin Lovell-Badge

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The cortical hem lacks stem cell potential despite expressing SOX9 and HOPX

Authors (5)

Alessia Caramello
Christophe Galichet
Miriam Llorian Sopena
Robin Lovell-Badge
Karine Rizzoti

Developmental Neurobiology

Published 1 October 2022

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A homozygous Y443C variant in the RNPC3 is associated with severe syndromic congenital hypopituitarism and diffuse brain atrophy

Authors (7)

Diğdem Bezen
Orkide Kutlu
Stephane Mouilleron
Karine Rizzoti
Mehul Dattani
Tulay Guran
Gözde Yeşil

American Journal of Medical Genetics Part A

Published 1 September 2022

Crick labs/ facilities

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Pathogenic variants in RNPC3 are associated with hypopituitarism and primary ovarian insufficiency

Authors (30)

Leyla Akin
Karine Rizzoti
Louise C Gregory
Beatriz Corredor
Polona Le Quesne Stabej
Hywel Williams
[...]
Luis A Pérez-Jurado
Iain Robinson
Robin Lovell-Badge
Jesús Argente
Mehul T Dattani

Genetics in Medicine

Published 1 February 2022

Crick labs/ facilities

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Editorial: Plasticity in the vertebrate pituitary, including regulatory mechanisms

Authors (3)

Romain Fontaine
Karine Rizzoti
Finn-Arne Weltzien

Frontiers in Endocrinology

Published 1 May 2021

Crick labs

Robin Lovell-Badge

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CRISPR/Cas9 deletion of SOX2 regulatory region 2 (SRR2) decreases SOX2 malignant activity in glioblastoma

Authors (7)

A Saenz-Antoñanzas
V Moncho-Amor
J Auzmendi-Iriarte
A Elua-Pinin
Karine Rizzoti
Robin Lovell-Badge
A Matheu

Cancers

Published 29 March 2021

Crick labs

Robin Lovell-Badge

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SOX2 is required independently in both stem and differentiated cells for pituitary tumorigenesis in p27-null mice

Authors (6)

Veronica Moncho Amor
Probir Chakravarty
Christophe Galichet
Ander Matheu
Robin Lovell-Badge
Karine Rizzoti

Proceedings of the National Academy of Sciences of the United States of America

Published 16 February 2021

Crick labs/ facilities

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Dentate gyrus development requires a cortical hem-derived astrocytic scaffold

Authors (4)

eLife

Published 4 January 2021

Crick labs/ facilities

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Cell population characterisation and discovery using single-cell technologies in endocrine systems

Authors (2)

Leonard YM Cheung
Karine Rizzoti

Journal of Molecular Endocrinology

Published 1 August 2020

Crick labs

Robin Lovell-Badge

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Studies of mice deleted for Sox3 and uc482: relevance to X-linked hypoparathyroidism

Authors (15)

Katherine U Gaynor
Irina V Grigorieva
Samantha M Mirczuk
Sian E Piret
Kreepa G Kooblall
Mark Stevenson
[...]
William D Fraser
Tertius Hough
Michael P Whyte
Robin Lovell-Badge
Rajesh Thakker

Endocrine Connections

Published 1 February 2020

Crick labs

Robin Lovell-Badge

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NOTCH activity differentially affects alternative cell fate acquisition and maintenance

Authors (6)

Leonard Cheung
Paul Le Tissier
Sam Goldsmith
Mathias Treier
Robin Lovell-Badge
Karine Rizzoti

eLife

Published 26 March 2018

Crick labs/ facilities

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Pivotal role of median eminence tanycytes for hypothalamic function and neurogenesis

Authors (2)

Molecular and Cellular Endocrinology

Published 13 August 2017

Crick labs

Robin Lovell-Badge

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Microglia Rank signaling regulates GnRH function and the Hypothalamic-Pituitary-Gonadal axis

Modeling the chondrocyte-derived osteoblasts formation process reveals its molecular signature and regulation network

The chordoid glioma PRKCA D463H mutation is a kinase inactive, gain-of-function allele that induces early-onset chondrosarcoma in mice

Gonadotrophs have a dual origin, with most derived from early postnatal pituitary stem cells

Hypopituitarism in Sox3 null mutants correlates with altered NG2-glia in the median eminence and is influenced by aspirin and gut microbiota

GEO entry GSE217648: SOX9-positive pituitary stem cells differ according to their position in the gland and maintenance of their progeny depends on context

SOX9-positive pituitary stem cells differ according to their position in the gland and maintenance of their progeny depends on context

Neural plate progenitors give rise to both anterior and posterior pituitary cells

Novel candidate regulators and developmental trajectory of pituitary thyrotropes

The cortical hem lacks stem cell potential despite expressing SOX9 and HOPX

A homozygous Y443C variant in the RNPC3 is associated with severe syndromic congenital hypopituitarism and diffuse brain atrophy

Pathogenic variants in RNPC3 are associated with hypopituitarism and primary ovarian insufficiency

Editorial: Plasticity in the vertebrate pituitary, including regulatory mechanisms

CRISPR/Cas9 deletion of SOX2 regulatory region 2 (SRR2) decreases SOX2 malignant activity in glioblastoma

SOX2 is required independently in both stem and differentiated cells for pituitary tumorigenesis in p27-null mice

Dentate gyrus development requires a cortical hem-derived astrocytic scaffold

Cell population characterisation and discovery using single-cell technologies in endocrine systems

Studies of mice deleted for Sox3 and uc482: relevance to X-linked hypoparathyroidism

NOTCH activity differentially affects alternative cell fate acquisition and maintenance

Pivotal role of median eminence tanycytes for hypothalamic function and neurogenesis

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