Impact of first SARS-CoV-2 infection variant on serological responses against Omicron: Findings from the SIREN study

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Ferdinando Insalata Ana Atti Edward Carr Ashley D Otter SIREN study group Sarah Foulkes Giulia Dowgier Agnieszka Hobbs Mary Wu Susan Hopkins Andre Charlett Rupert Beale Victoria Hall
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Abstract

INTRODUCTION: Despite the existing hybrid immunity, a sharp increase in SARS-CoV-2 reinfections was observed worldwide following Omicron variant emergence. We investigated whether the first infecting variant indelibly shapes serological responses against Omicron (BA.1 and BA.2) reinfection. METHODS: Participants with a sequence-confirmed Alpha (n = 23) or Delta (n = 10) first infection before third vaccine dose (V3) that subsequently had a BA.1 or BA.2 reinfection were selected. Sera were tested for anti-SARS-CoV-2 spike (anti-S) and live virus microneutralisation (LV-N) against Ancestral, Alpha, Delta, Omicron BA.1 and BA.2. Antibody responses and waning post-V3 were compared by first infection variant using mixed-effect models, as well as inferred titres days before reinfections. Individual's neutralisation responses were compared 12 weeks post-V3, among those with Alpha and Delta primary infection. RESULTS: After V3, those with Delta first infection had higher LV-N Omicron BA.1 titres (fold difference (FD) = 2.7, p = 0.05) compared to Alpha primary infection. Participants with Delta first infection presented higher LV-N BA.1 (FD = 1.89, p = 0.004) and LV-N BA.2 (FD = 2.06, p = 0.001) titres pre-Omicron reinfections. Individuals' neutralisation responses against Ancestral were higher than any other subsequent variants, regardless of first infection variant. CONCLUSIONS: A previous Delta SARS-CoV-2 infection induced a higher serological response against a subsequent Omicron infection when compared to Alpha first infections.

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Journal Influenza and Other Respiratory Viruses
Volume 20
Issue number 2
Pages e70204
Available online
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Publisher website (DOI) 10.1111/irv.70204
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Europe PubMed Central 41725262
Pubmed 41725262

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