Osier lab

Decoding Immune Responses Laboratory

We aim to decode the fine molecular characteristics of the protective immune response against P. falciparum malaria and ultimately contribute to the design of highly effective vaccines.

We will dissect the Fab and Fc ends of IgG and IgM antibodies, comparing samples from protected versus susceptible volunteers in the CHMI study. 

First, we will characterize and compare antigen-specific B and T-cell repertoires. 

Second, we will isolate, recombinantly express and elucidate the molecular characteristics of highly potent functional monoclonal antibodies (mAbs) and characterize their linked Tfh and B cell profiles. 

Third, we will quantify and compare the expression pattern and cellular distribution of Fcg receptors (FcgR) on autologous immune cells.