Eva Lana-Elola

Hippocampal circuit-specific enhancement of GABA-inhibition caused by discrete gene regions in a Down syndrome model

Preprint

Authors (6)

Saad B Hannan
Eva Lana-Elola
Sheona Watson-Scales
Elizabeth MC Fisher
Victor Tybulewicz
Trevor G Smart

bioRxiv

Published 24 July 2025

Crick labs

Victor Tybulewicz

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DYRK1A kinase triplication is the major cause of Otitis Media in Down Syndrome

Preprint

Authors (18)

Hilda Tateossian
Amy Southern
Pratik Vikhe
Eva Lana-Elola
Sheona Watson-Scales
Dorota Gibbins
[...]
Sara Wells
Heena V Lad
Elizabeth MC Fisher
Victor Tybulewicz
Steve DM Brown

eLife

Published 7 January 2025

Crick labs/ facilities

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Dissecting the contribution of human chromosome 21 syntenic regions to recognition memory processes in adult and aged mouse models of Down syndrome

Authors (7)

Tara Canonica
Emma J Kidd
Dorota Gibbins
Eva Lana-Elola
Elizabeth MC Fisher
Victor Tybulewicz
Mark Good

Frontiers in Behavioral Neuroscience

Published 10 July 2024

Crick labs/ facilities

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Developmental dynamics of human cardiogenesis: A multi-omic reference and its disruption in Trisomy 21

Preprint

Authors (30)

James Cranley
Kazumasa Kanemaru
Semih Bayraktar
Vincent Knight-Schrijver
Rebecca Hulbert
Eva Lana-Elola
[...]
Minal Patel
Richard Tyser
Victor Tybulewicz
Sanjay Sinha
Sarah A Teichmann

bioRxiv

Published 29 April 2024

Crick labs/ facilities

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Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome

Authors (20)

Eva Lana-Elola
Rifdat Aoidi
Miriam Llorian Sopena
Dorota Gibbins
Callan Buechsenschuetz
Claudio Bussi
[...]
Laurent Meijer
Bram Snijders
Maximiliano Gutierrez
Elizabeth MC Fisher
Victor Tybulewicz

Science Translational Medicine

Published 24 January 2024

Crick labs/ facilities

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Craniofacial dysmorphology in Down syndrome is caused by increased dosage of Dyrk1a and at least three other genes

Authors (10)

Yushi Redhead
Dorota Gibbins
Eva Lana-Elola
Sheona Watson-Scales
Lisa Dobson
Matthias Krause
Karen J Liu
Elizabeth MC Fisher
Jeremy BA Green
Victor Tybulewicz

Development

Published 15 April 2023

Crick labs

Victor Tybulewicz

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Genetic dissection of triplicated chromosome 21 orthologs yields varying skeletal traits in Down syndrome model mice

Authors (11)

Kourtney Sloan
Jared Thomas
Matthew Blackwell
Deanna Voisard
Eva Lana-Elola
Sheona Watson-Scales
Daniel L Roper
Joseph M Wallace
Elizabeth MC Fisher
Victor Tybulewicz
Randall J Roper

Disease Models and Mechanisms

Published 1 April 2023

Crick labs

Victor Tybulewicz

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Comprehensive phenotypic analysis of the Dp1Tyb mouse strain reveals a broad range of Down syndrome-related phenotypes

Authors (26)

Eva Lana-Elola
Heather Cater
Sheona Watson-Scales
Simon Greenaway
Jennifer Mueller-Winkler
Dorota Gibbins
[...]
Michelle Simon
Ann-Marie Mallon
Sara Wells
Elizabeth MC Fisher
Victor Tybulewicz

Disease Models and Mechanisms

Published 1 October 2021

Crick labs/ facilities

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Maternal iron deficiency perturbs embryonic cardiovascular development in mice

Authors (22)

Jacinta I Kalisch-Smith
Nikita Ved
Dorota Szumska
Jacob Munro
Michael Troup
Shelley E Harris
[...]
Timothy J Mohun
Samira Lakhal-Littleton
Sarah De Val
Eleni Giannoulatou
Duncan B Sparrow

Nature Communications

Published 8 June 2021

Crick labs/ facilities

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Interaction of sexual dimorphism and gene dosage imbalance in skeletal deficits associated with Down syndrome

Authors (9)

Jared R Thomas
Jonathan LaCombe
Rachel Long
Eva Lana-Elola
Sheona Watson-Scales
Joseph M Wallace
Elizabeth MC Fisher
Victor Tybulewicz
Randall J Roper

Bone

Published 1 July 2020

Crick labs

Victor Tybulewicz

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Gene expression dysregulation domains are not a specific feature of Down syndrome

Authors (12)

Helena Ahlfors
Nnneka Anyanwu
Edvinas Pakanavicius
Natalia Dinischiotu
Eva Lana-Elola
Sheona Watson-Scales
[...]
Frances Wiseman
James Briscoe
Karen Page
Elizabeth MC Fisher
Victor Tybulewicz

Nature Communications

Published 6 June 2019

Crick labs/ facilities

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Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration

Authors (19)

Sheona Watson-Scales
Bernadett Kalmar
Eva Lana-Elola
Dorota Gibbins
Federica La Russa
Frances Wiseman
[...]
Y Eugene Yu
Damaris Bennett
Linda Greensmith
Elizabeth MC Fisher
Victor Tybulewicz

PLOS Genetics

Published 10 May 2018

Crick labs/ facilities

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Aging rather than aneuploidy affects monoamine neurotransmitters in brain regions of Down syndrome mouse models

Authors (12)

Alain D Dekker
Yannick Vermeiren
Christelle Albac
Eva Lana-Elola
Sheona Watson-Scales
Dorota Gibbins
[...]
Debby Van Dam
Elizabeth MC Fisher
Victor Tybulewicz
Marie-Claude Potier
Peter P De Deyn

Neurobiology of Disease

Published 1 September 2017

Crick labs

Victor Tybulewicz

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Genetic dissection of Down syndrome-associated congenital heart defects using a new mouse mapping panel

Authors (9)

Eva Lana-Elola
Sheona Watson-Scales
Amy Slender
Dorota Gibbins
Alexandrine Martineau
Charlotte Douglas
Timothy Mohun
Elizabeth MC Fisher
Victor Tybulewicz

eLife

Published 14 January 2016

Crick labs/ facilities

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Alterations to dendritic spine morphology, but not dendrite patterning, of cortical projection neurons in Tc1 and Ts1Rhr mouse models of Down Syndrome

Authors (8)

Matilda A Haas
Donald Bell
Amy Slender
Eva Lana-Elola
Sheona Watson-Scales
Elizabeth MC Fisher
Victor Tybulewicz
Francois Guillemot

PLOS ONE

Published 1 January 2013

Crick labs/ facilities

Full details

Down syndrome: searching for the genetic culprits

Authors (4)

Eva Lana-Elola
Sheona D Watson-Scales
Elizabeth MC Fisher
Victor Tybulewicz

Disease Models and Mechanisms

Published 1 September 2011

Crick labs

Victor Tybulewicz

Full details

Down's syndrome-like cardiac developmental defects in embryos of the transchromosomic Tc1 mouse

Authors (7)

Louisa Dunlevy
Mike Bennett
Amy Slender
Eva Lana-Elola
Victor Tybulewicz
Elizabeth MC Fisher
Timothy Mohun

Cardiovascular Research

Published 16 June 2010

Crick labs

Victor Tybulewicz

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Hippocampal circuit-specific enhancement of GABA-inhibition caused by discrete gene regions in a Down syndrome model

DYRK1A kinase triplication is the major cause of Otitis Media in Down Syndrome

Dissecting the contribution of human chromosome 21 syntenic regions to recognition memory processes in adult and aged mouse models of Down syndrome

Developmental dynamics of human cardiogenesis: A multi-omic reference and its disruption in Trisomy 21

Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome

Craniofacial dysmorphology in Down syndrome is caused by increased dosage of Dyrk1a and at least three other genes

Genetic dissection of triplicated chromosome 21 orthologs yields varying skeletal traits in Down syndrome model mice

Comprehensive phenotypic analysis of the Dp1Tyb mouse strain reveals a broad range of Down syndrome-related phenotypes

Maternal iron deficiency perturbs embryonic cardiovascular development in mice

Interaction of sexual dimorphism and gene dosage imbalance in skeletal deficits associated with Down syndrome

Gene expression dysregulation domains are not a specific feature of Down syndrome

Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration

Aging rather than aneuploidy affects monoamine neurotransmitters in brain regions of Down syndrome mouse models

Genetic dissection of Down syndrome-associated congenital heart defects using a new mouse mapping panel

Alterations to dendritic spine morphology, but not dendrite patterning, of cortical projection neurons in Tc1 and Ts1Rhr mouse models of Down Syndrome

Down syndrome: searching for the genetic culprits

Down's syndrome-like cardiac developmental defects in embryos of the transchromosomic Tc1 mouse

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